Title | Description | Eligibility | Compensation | Researchers |
Diet in IBS Research Study | The Diet in IBS Research Study is a clinical crossover research study which is the first to investigate the effects of dietary gluten and amylase trypsin inhibitors (ATIs) on irritable bowel syndrome (IBS). The trial is being led by Drs. Premysl Bercik and M. Ines Pinto-Sanchez in the Farncombe Digestive Disease Research Institute at McMaster University. The Study Coordinator is PhD Candidate Caroline Seiler and the co-investigators include Dr. Elena Verdu, Dr. Stephen Collins, Dr. Paul Moayyedi, and Dr. Andrea Nardelli. This study is supported by the Canadian Digestive Health Foundation and a Society for the Study of Celiac Disease (SSCD) grant for Non-Celiac Gluten/Wheat Sensitivity sponsored by the Nestle Research Center, Nestec SA to Drs. Bercik and Pinto-Sanchez. Find out more at https://healthsci.mcmaster.ca/diet-in-ibs Contact Caroline Seiler for more information at seilercl@mcmaster.ca | Adults aged 18+ with an IBS diagnosis based on Rome IV criteria who previously improved while on a gluten-free diet, are able to comply with the study procedures, and have signed the Informed Consent may be eligible for the study. | We will offer compensation and all the costs for the study visits will be covered. | Dr. Premysl Bercik, Dr. M. Ines Pinto-Sanchez, Caroline Seiler |
Benralizumab regulates atopic dermatitis through effects on eosinophils, basophils and innate lymphoid type 2 cells | There are not many medications available that are fully effective and can be used long-term for treatment of atopic dermatitis. Benralizimab is a monoclonal antibody used for treatment of a type of asthma called “eosinophilic asthma”. Atopic dermatitis is also associated with elevated levels of eosinophils, and we would like to determine if benralizumab is effective in patients with atopic dermatitis. This is a placebo-controlled study with 7 visits over 9 weeks. Contact Christiane Whetston for more information at whetstoc@mcmaster.ca | Male and female patients with moderate-to-severe atopic dermatitis aged 18-65. | $250 plus paid parking and food vouchers | Christiane Whetston, Dr. Ruth Cusack, Dr. Gauvreau, Dr. Sehmi, Dr. Lima, Dr. O’Byrne |
The effect of sex hormone levels during the menstrual cycle on capsaicin evoked cough responses in mild allergic asthmatics. | All participants will undergo one screening visit to determine eligibility for the study, and 2 further subsequent visits. If you are a female participant on the oral contraceptive pill you will be assessed once between day 1-5 (during your pill break) and again between day 21-25. If you are a female participant with a natural cycle you will be assessed once between day 1 to day 5 of your menstrual cycle (i.e. during menstruation) and again between day 21-25 of your menstrual cycle. Men will be assessed in the same method, once between day 1 to 5, and once between day 21-25. Contact Christiane Whetston for more information at whetstoc@mcmaster.ca | Males and females with mild allergic asthma aged 18-35. | $100 plus paid parking and food vouchers | Dr. Ruth Cusack, Dr. Gauvreau, Dr. Sehmi, Dr. Imran Satia, Dr. O’Byrne |
McMaster Institute for Infectious Disease Research COVID-19 Saliva-Protocol ImplemenTation Study | With this study, we aim to assess the success, impact, and practicality of saliva-based SARS-CoV-2/COVID-19 testing for scale up to include testing for large asymptomatic populations in a university laboratory setting. In addition to prevention of community, workplace, and school spread of SARS-CoV-2/COVID-19, we believe the impact of saliva-based routine testing on factors such as quality of life in the training/workplace environment will be substantially improved. Contact Nakita Buenbrazo for more information at iidr.covidspit@gmail.com | Participants must be: – >18 years of age – Working at least 2 days per week – Full-time employee or student – Able to refrain from brushing teeth, eating and drinking for at least 1 hour before providing the sample. – Able to check their email at least once per day | N/A | Dr. Dawn Bowdish and Dr. Eric Brown, Nakita Buenbrazo |
| How are changes in the pacing and rhythm of language processed? | This study aims to investigate the role of rhythm and timing on how language is processed. As part of this study, participants will listen to auditory stimuli presented to them via earphones and watch a movie. Concurrently, EEG will be recorded to monitor their brain activity through electrodes placed on the scalp. Please visit our website or contact Fareeha Rana at ranafs@mcmaster.ca for more information. | Adults aged 18-35, with no history of neurological disorders or disease (eg. concussion etc.), must not be taking any medication that interferes with the CNS (e.g. anxiety/depression meds), no hearing impairments | $30 compensation total for a 2 hour session | Fareeha Rana, supervised by Dr. E. Service and Dr. J. Connolly. |
